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Long Descriptions of images in Guides: Pyramid of Different Types of Studies

Long Description of Image of Pyramid of Different Types of Studies

 

Long Description of Pyramid of Types of Studies Image

As you move up the pyramid the study designs are more rigorous and allow for less bias or systematic error that may distract you from the truth.

  1. Bottom of the Pyramid

Background Information/Expert Opinion

  1. Next level up on the Pyramid

Case series and Case reports consist of collections of reports on the treatment of individual patients or a report on a single patient. Because they are reports of cases and use no control groups to compare outcomes, they have little statistical validity.

Case control studies are studies in which patients who already have a specific condition are compared with people who do not have the condition. The researcher looks back to identify factors or exposures that might be associated with the illness. They often rely on medical records and patient recall for data collection. These types of studies are often less reliable than randomized controlled trials and cohort studies because showing a statistical relationship does not mean than one factor necessarily caused the other.

  1. Next level up of the Pyramid

Cohort studies identify a group of patients who arealready taking a particular treatment or have an exposure, follow them forward over time, and then compare their outcomes with a similar group that has not been affected by the treatment or exposure being studied. Cohort studies are observational and not as reliable as randomized controlled studies, since the two groups may differ in ways other than in the variable under study.

  1. Next level of Pyramid

Randomized controlled clinical trials

Definition: Randomized controlled clinical trials are carefully planned experiments that introduce a treatment or exposure to study its effect on real patients. They include methodologies that reduce the potential for bias (randomization and blinding) and that allow for comparison between intervention groups and control (no intervention) groups. A randomized controlled trial is a planned experiment and can provide sound evidence of cause and effect.

  1. Top of the pyramid

Meta-analysis

Definition: A Meta-analysis will thoroughly examine a number of valid studies on a topic and mathematically combine the results using accepted statistical methodology to report the results as if it were one large study.

Systematic Reviews

Definition: Systematic Reviews focus on a clinical topic and answer a specific question. An extensive literature search is conducted to identify studies with sound methodology. The studies are reviewed, assessed for quality, and the results summarized according to the predetermined criteria of the review question.